SOCS1

SOCS1 stands for: Suppressor Of Cytokine Signaling 1. SOCS1 is a negative regulator of T cell signaling by cytokines, the small proteins critical in controlling the growth and activity of immune cells responding to pathogens and cancer. We identified SOCS1 as a top...

Regnase-1

Regnase-1 is an endonuclease that regulates immune responses by degrading the messenger RNA (mRNA) of pro-inflammatory proteins. Using our in vivo CRISPR2TM dual gene-editing screening approach, we identified Regnase-1 and SOCS1 as the genome’s top dual-edit...

USP1

USP1 was identified using our Targeted Oncology CRISPRomics platform due to its profile as selectively essential in certain biomarker-enabled cancer cell models and its role in DNA damage repair processes (DDR). USP1 is a member of the ubiquitin-specific processing...