- Regnase-1 is an endonuclease that regulates immune responses by degrading the messenger RNA (mRNA) of pro-inflammatory proteins.
- Using our in vivo CRISPR2TM dual gene-editing screening approach, we identified Regnase-1 and SOCS1 as the genome’s top dual-edit combination in T cells, synergizing to drive best-in-biology activity in mouse cancer models that are refractory to all other therapies.
- We have translated these findings to our second eTIL program, KSQ-004EX, a Regnase-1 + SOCS1 dual-edited eTIL.
