• USP1 was identified using our Targeted Oncology CRISPRomics platform due to its profile as selectively essential in certain biomarker-enabled cancer cell models and its role in DNA damage repair processes (DDR).
  • USP1 is a member of the ubiquitin-specific processing (UBP) family of proteases with a role in DDR distinct from other mechanisms currently being evaluated in the clinic, including PARP inhibitors, which have shown significant clinical utility and opened up a new field of targeted oncology exploiting an approach known as “synthetic lethality.”