• SOCS1 stands for: Suppressor Of Cytokine Signaling 1. SOCS1 is a negative regulator of T cell signaling by cytokines, the small proteins critical in controlling the growth and activity of immune cells responding to pathogens and cancer.
  • We identified SOCS1 as a top target using our Immune CRISPRomics platform. Editing SOCS1 in TIL using CRISPR/Cas9 has demonstrated remarkable tumor-killing activity in in vivo mouse cancer models, including those refractory to inhibition by PD-1.
  • Our lead eTIL program, KSQ-001EX, is a CRISPR/Cas9 gene-edited eTIL with the SOCS1 gene inactivated. We are currently evaluating KSQ-001EX in the clinic in patients with a variety of treatment-refractory solid tumors.