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Principal Scientist / Associate Director, Medicinal Chemistry

KSQ Therapeutics, Inc. has an immediate opening for an Associate Director / Director, Medicinal Chemistry position in Cambridge, MA. KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.

Position summary

KSQ Therapeutics is seeking an exceptional, innovative and highly motivated Principal Scientist / Associate Director: Medicinal Chemistry to apply fundamentals of synthesis, SAR and structure-based design toward the optimization of chemical matter to advance our portfolio of drug development programs. This person will contribute to the company’s emerging NCE drug design organization and participate scientifically to build a strong portfolio of novel drug candidates. As part of the team of scientists at KSQ Therapeutics, this individual will have responsibility for biological data interpretation, design of molecules, and development of structure-activity relationship as well as execution of the synthetic plan in collaboration with CRO partners. As part of a lead progression team, this individual will set the small molecule drug discovery strategy on one or more programs from hit triaging, hit-to-lead and lead optimization to deliver drug candidates that benefit patients’ lives. The successful individual will join a dynamic, enthusiastic, interdisciplinary, and collaborative team of scientists.


  • Responsible for interactions with CRO partners ensures priorities and objectives are consistent with the goals of the multidisciplinary team and the drug discovery programs
  • Implement and seamlessly oversee synthesis, characterization and compound submission for biological profiling at CRO partner facility
  • Review, interpret and QC data from CRO partners
  • Contribute scientifically and intellectually at the drug design level on multiple programs
  • Must be able to travel periodically, including internationally, to develop and foster collaborations with CRO partners
  • Develop and deliver scientific reports and presentations internally or externally as needed
  • Function in a scientific expert role as part of an interdisciplinary team contributing to the design and execution of experiments in support of our research activities and project goals.
  • Participate in various aspects of this new fast-pace company from building out the capabilities, contributing intellectually and to generating data in a fast and efficient manner.


  • PhD in chemistry with 8+ years of industry experience with a focus on small molecule drug discovery or BS/MS with 12+ years of comparable work-relevant experience in the field of small molecule drug design
  • Experience interfacing with, and providing scientific guidance to, CRO partners and ability to work efficiently in an outsourced model
  • Demonstrated expertise and a track record of success in advancing discovery programs from target validation through lead optimization
  • Expertise of successfully prosecuting different biological target classes and varied chemotypes
  • A track record of communicating scientific concepts and strategies effectively, including a publication record in peer reviewed journals
  • Excellent verbal and written communication and interpersonal skills to work within a project team setting, across functions, and within academic and industry collaborations
  • Ability to independently solve problems, to think critically and creatively as part of a fast-paced research team.
  • Commitment to quality, attention to detail, and team player mentality is a must.

Apply Now!