Careers

At KSQ Therapeutics, we are always looking for strong leaders to join our team.
Contact us about current job opportunities.

A NOTE TO RECRUITERS

To be able to manage our flow of candidates we do not accept unsolicited resumes from any source other than directly from the candidates for current or future positions. Submission of unsolicited referrals and/or resumes in advance of a signed agreement between KSQ and the recruiter are deemed gratuitous and KSQ will not be obligated or bound in any way to pay any referral or other fees if such person is hired. Thank you in advance for your adherence to our process. For any hiring needs, please contact us.

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Senior Scientist/Principal Scientist in Preformulation

KSQ Therapeutics is seeking an exceptional, innovative and highly motivated Senior Scientist/Principal Scientist in the Drug Metabolism and Pharmacokinetics and Preformulation Function to advance rapidly expanding and growing KSQ’s drug discovery portfolio to development and clinic. This person will execute the preformulation strategy for KSQ leads and drug candidates in exploratory research and development studies and act as a key liaison to the CMC team on clinical formulation development for IND and FIH. The person will support PK, PK/PD, drug discovery in vivo pharmacology studies, and toxicology studies in designing and developing vehicles and employ the enabling formulation approaches for poorly water-soluble compounds. In addition, the person will support preclinical supply manufacture through CROs and/or in-house experimental efforts. The person will work closely with research team members, technical operation, and clinical development groups to develop vehicles and formulation to advance assets into early clinical studies. This person is expected to contribute to and exert influence across late stage drug discovery/early drug development programs both scientifically and operationally to ensure the successful advancement of NCE candidates. The successful individual will join a dynamic, enthusiastic, interdisciplinary, and collaborative team of scientists.

Responsibilities

  • Assist preformulation function in a hybrid model at KSQ, develop interactions with CRO partners, and set up the necessary internal infrastructure.
  • Work closely with in-life groups to design and develop fit-for-purpose preclinical formulations (conventional and enabling) for PK, PK/PD, drug discovery in vivo pharmacology, and toxicology studies to enable robust candidate selection and progression.
  • Design and interpret preformulation studies including forced degradation analysis, solubility/dissolution measurement, stability assessment, and solid-state characterization using techniques such as, HPLC, particle size measurement, XRPD, DSC, TGA, vapor-sorption analysis, PLM, etc. on potential drug candidates, salt screening and characterization, with the purpose of defining their physicochemical and biopharmaceutical properties relevant to the route of administration.
  • Collaborate with the Process Chemistry team to identify the final form of API for advancing programs.
  • Convert formulations/products data into knowledge required for regulatory filings, e.g. IND and NDA. Assist in drafting the relevant sections of these documents.
  • Must be able to travel periodically, including internationally, to develop and foster collaborations with CRO partners
  • Develop and deliver scientific reports and presentations internally or externally as needed

Requirements

  • PhD in pharmaceutical sciences or related discipline with a minimum of 5 years, or BS/MS with a minimum of 8 years of relevant industry experience is required.
  • Experience interfacing with and providing scientific and technical guidance to CRO partners and proven ability to work efficiently in a hybrid model.
  • Solid knowledge and experience in physicochemical characterization of small molecules, conducting solubility/dissolution measurements, designing and executing formulation screening experiments, conducting stability testing, formulation development for nonclinical research studies, and applying enabling formulation technologies (i.e., nanocrystal and amorphous solid dispersion) for oral drug delivery.
  • Familiarity with regulatory requirements and quality standards in the US and EU including cGMP and GLP guidelines is a plus.
  • Proven ability to execute projects under aggressive timelines and provide creative solutions to complex pharmaceutics issues in a dynamic and fast paced environment.
  • Excellent verbal and written communication and interpersonal skills to work with the project teams and across functions.
  • Commitment to quality, attention to detail, and team player mentality in a highly dynamic environment is a must.

Apply Now!