Careers

About KSQ Therapeutics

At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015, KSQ is a clinical-stage biotech that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development.

Position Summary:

KSQ Therapeutics, Inc. is seeking a self-motivated and dependable Associate Scientist/Senior Associate Scientist to join our Immuno-Biology team. The candidate will work in a multidisciplinary team to discover novel immunotherapeutic targets for the treatment of cancer. Our ideal candidate thrives in a collaborative research environment that demands scientific rigor and technical excellence while encouraging a positive work/life balance. The candidate will perform experimental activities and analysis, with mentor supervision and feedback. Applicants with an interest in the rapidly emerging NK cell therapy field and experience in cell culture, CRISPR-Cas9 technology and cell-based assays are strongly encouraged to apply.

Requirements

The (Senior) Associate Scientist’s key responsibilities will include the following:

• Contribute to genome-wide CRISPR/Cas9 screens in NK cells
• Isolate, expand, edit, and characterize primary cord blood-NK cells
• Design and execute cell-based functional assays for the validation of NK cell therapy edits
• Develop and deliver scientific presentations and reports in a fast and efficient manner
• Participate in various aspects of small company capability building

Requirements

• B.S. or M.S. in biology, immunology, or relevant field
• 0-3 years of experience in a relevant academic or biopharmaceutical setting
• Proficiency in mammalian cell culture and aseptic cell culture techniques
• Experience with cell-based assays (killing assays, proliferation, functionality, etc) and multi-color flow cytometry
• Experience in basic molecular biology techniques, including DNA/RNA isolation, PCR (including qRT), and plasmid cloning is a plus
• Experience with CRISPR/Cas9 gene-editing tools is a plus
• Demonstrated commitment to quality and attention to details
• Excellent verbal/written communication and presentation skills
• Ability to contribute to multiple parallel projects under demanding timelines
• A record of achievement in research and scientific creativity in the areas of immunology, oncology, inflammation, immuno-oncology, and/or drug discovery