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Principal Scientist/Associate Director, Toxicology


KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.


KSQ Therapeutics is seeking an exceptional, innovative and highly motivated Principal Scientist/Associate Director, Toxicology to apply their experience towards the advancement of impactful therapies across a broad portfolio of small and large molecules as well as adoptive cell therapies in the oncology and immuno-oncology space. This person will influence the emerging safety strategy for early discovery programs and contribute to the advancement of molecules from lead optimization and candidate selection into clinical development. As part of the team of scientists at KSQ Therapeutics, the successful candidate will have responsibility for predicting pharmacologically mediated toxicity, the design of safety studies to address them, the design, monitoring and conduct of IND-enabling studies, cross functional data interpretation and communication, as well as input on the strategy for assessing toxicology across an expanding portfolio. We are seeking motivated individuals to join a fast-paced and dynamic environment in a growing biotechnology company.


  • Conduct safety target assessments to predict pharmacologically-mediated toxicity and design studies to investigate their relevance.
  • Enable cross-functional discovery small molecule, large molecule and adoptive cell therapy programs advancement through lead optimization, candidate selection and IND-enabling studies.
  • Review and edit toxicology protocols and reports which also includes responsibility for bioanalytical, toxicokinetic and pathology contributor reports; perform study monitoring for critical safety studies (requires periodic travel).
  • Write/edit integrated toxicology sections of regulatory documents (pre-IND briefing books, sections 2.6.2 and 2.6.6 of IND, IB, DSUR).
  • Effectively condense complex data sets and topics to salient points for both internal and external communication.
  • Influence the development of an immunotoxicology strategy in conjunction with other KSQ scientists for broad implementation across immuno-oncology portfolio.
  • Excellent verbal and written communication and interpersonal skills to work within a project team setting, across functions, and within academic and industry collaborations.
  • Ability to independently solve problems and think creatively as part of a fast-paced research team.


  • PhD in toxicology or related field or DVM with 7+ or MS degree with 15+ years of relevant industry experience; academic or industry post-doctoral research a plus.
  • Extensive experience interfacing with, and providing scientific guidance to, CRO partners and proven ability to work efficiently in a hybrid model.
  • Demonstrated expertise and track record of success in advancing discovery programs from target validation, through lead optimization, candidate selection and clinical development.
  • Previous experience writing and/or editing sections 2.6.2 and 2.6.6 of an IND regulatory submission.
  • Ability to navigate complex immunology targets and work cross-functionally to advance immunotoxicology efforts.
  • Ability to influence in vitro/in vivo toxicology strategy and think critically and creatively as part of a fast-paced research team.
  • Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally.
  • Demonstrated commitment to quality, attention to detail, and team player mentality.
  • DABT certification preferred.

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