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Principal Scientist/Associate Director, Non-clinical DMPK


KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.


KSQ Therapeutics is seeking an exceptional, innovative and highly motivated Principal Scientist/Associate Director in the newly formed Non-Clinical Drug Metabolism and Pharmacokinetics and Formulation Function to advance rapidly expanding and growing KSQ’s drug discovery portfolio to development and clinic. The candidate should have a demonstrated history of DMPK representation in cross-functional drug discovery project teams as well as experience working with CROs. This person will have established a track record of successful contribution to NCE project teams from discovery to preclinical development candidate selection and participation in IND submission. This individual will be an experienced DMPK professional with working knowledge in small molecule drug metabolism, transporter, pharmacokinetics, bioanalysis, PK/PD modeling and simulation, and human PK and dose prediction. A deep expertise in drug-drug interaction (DDI) assessment will be an important attribute for a successful candidate. This person is expected to contribute to and exert influence across multiple early-mid stage drug discovery programs, both scientifically and strategically to ensure the successful advancement of NCE candidates. The successful individual will join a dynamic, enthusiastic, interdisciplinary, and collaborative team of scientists.


  • Represent all aspects of DMPK within cross-functional drug discovery teams and contribute to enable small molecule drug discovery programs to progress from discovery to clinical trial
  • Design, execute and interpret enabling DMPK studies as well as author high-quality documents supporting regulatory interactions and filings. Analyze and interpret data as well as integrate DMPK study results within the overall project.
  • Provide PBPK modeling expertise for DDI assessment and make recommendations to mitigate DDIs
  • Work collaboratively with project teams to develop and execute translational PK and/or PK/PD modeling.
  • Interface with CROs to ensure quality and efficiency of outsourced DMPK studies
  • Provide scientific and technical guidance to CRO partners to enable KSQ’s small molecule drug discovery portfolio progression toward development and entry into clinic trials
  • Must be able to travel periodically, including internationally, to develop and foster collaborations with CRO partners
  • Develop and deliver scientific reports and presentations internally or externally as needed


  • PhD in pharmaceutical or related sciences with 8+ years of industry experience or BS/MS in pharmaceutical or related sciences with 12+ years of industry experience in NCE ADME and pharmacokinetics
  • Experience interfacing with, and providing scientific and technical guidance to CROs and proven ability to work efficiently in a hybrid model
  • Experience using at least one industry standard PBPK modeling package (such as GastroPlus or Simcyp) to integrate available data and apply PBPK models to assess DDI for combination therapeutic drug development in both discovery and clinical setting
  • Demonstrated success in contribution to programs from discovery to preclinical development candidate selection and participation in NCE IND/NDA submission
  • Broad working knowledge in small molecule drug metabolism, transporter, pharmacokinetics, bioanalysis, PK/PD modeling and simulation, and human PK and dose prediction
  • Excellent verbal and written communication and interpersonal skills to work with project teams, across functions, and within academic and industry collaborations
  • Commitment to quality, attention to detail, and a team player mentality in a highly dynamic environment is a must.

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