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Senior Scientist/Associate Principal Scientist, Immunobiology

About KSQ Therapeutics

KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.


KSQ Therapeutics is seeking an exceptional and highly motivated Senior / Associate Principal to join the Immunobiology group. This individual will serve as an expert immunologist to support KSQ-003, an autologous TIL therapy, as well as develop next generation adoptive cell therapies. This is a unique opportunity to learn and develop in a highly dynamic and interdisciplinary environment.


  • Design and establish assays to assess the biological impact of modification of KSQ’s targets in primary human T cells and TILs.
  • Develop novel methods to isolate and expand TILs from diverse tumor types
  • Reliably deliver data to support IND submissions
  • Support ongoing target ID/validation work, including assessing MoA of novel adoptive cell therapy targets
  • Develop and deliver scientific presentations and reports in a fast and efficient manner
  • Serve as scientific mentor for junior colleagues


  • Ph.D. in Immunology or a related discipline, with a postdoc and 2-3 years industry experience. Alternatively, BS/MS candidates with 10+ years immunology industry experience will be considered. Expert in T cell biology
  • Expertise with standard immunological laboratory techniques, including flow cytometry, ELISA/MSD/Luminex, cell culture, western blotting, molecular biology (qRT-PCR, cloning)
  • Hands-on experience in the design, execution and analysis of functional assays using primary immune cells
  • Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally
  • Demonstrated productivity as evidenced by quality publications in peer-reviewed journals
  • Ability to think critically and creatively in a fast-paced environment.
  • Hands on experience in immuno-oncology, especially working with human tumor infiltrating lymphocytes
  • Experience using CRISPR-based genome-editing techniques to engineer cells

Apply Now!