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Scientist/Sr Scientist, Pharmacology

About KSQ Therapeutics

KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.

Position Summary

KSQ Therapeutics, Inc. is seeking an exceptional and highly motivated Senior Associate Scientist/Scientist to join the Pharmacology group. The successful applicant will contribute to in vivo pharmacology efforts to support the advancement of our pre-clinical Oncology and Immuno-Oncology small and large molecule pipeline. This is a unique opportunity to learn and develop in a highly dynamic and interdisciplinary environment.


  • Independently execute on a wide variety of in vivo techniques across multiple projects with delivery of high quality data
  • Work collaboratively within department and across departments to effectively achieve project goals and timelines
  • Work enthusiastically as part of an interdisciplinary team


  • B.S. with 3-5+ years of experience in Pharmacology in an industry setting or MSc with 1-3+ years of drug discovery experience.
  • Experience in immune-oncology in vivo models including; cell culture, compound preparation, and administration (e.g. i.v., s.c., p.o.), syngeneic, CDX, PDX implantation and measurement.
  • 1-3 years of Flow cytometry experience is required.
  • Experience in developing and executing ex vivo assays to investigate target and/or therapeutic MOA by flow cytometry, RNA-seq, DNA-NGS is recommended.
  • Demonstrated experience with independent organization and execution of in vivo studies to evaluate tolerability, efficacy and mechanism of action of therapeutic agents
  • Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally.

Apply Now!