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Head of Technical Operations

About KSQ Therapeutics

KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.

KSQ is currently conducting a search for our first Head of Technical Operations. The ideal candidate should have experience working in/leading technical operation teams in the areas of small molecule discovery and development, monoclonal antibody discovery and development and cellular therapies. Our lead programs include a small molecule program and a Cell-based programs.

The candidate will be responsible for:

  • Creation and full-time management of CMO network, including critical technical capability evaluation, work order development, price negotiation, site visitation, and communication strategy
  • Supply modeling and planning for non-clinical, IND-enabling, clinical, and commercial activities
  • Coordination of CMC analytical needs and build-out of compliant analytical program
  • Build-out and maintenance of dedicated CMC timeline and budget
  • Centralized management of process development and tech-transfer to CMOs
  • Drafting, revision, and review of regulatory filing documents
  • CMC risk management and mitigation
  • Coordination of Quality assessments initially utilizing quality consultants


  • A minimum of 10+ years of biotech industry experience
  • Advanced science degree, PhD preferred
  • Highly motivated, hands-on individual motivated by working independently, as well as part of a multidisciplinary team
  • Strong interpersonal skills, capable of working in the fast paced environment of a biotechnology start-up.

Apply Now!