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Senior Scientist, Computational Biology

Job Reference: #005

KSQ Therapeutics, Inc. has an immediate opening for a Senior Scientist, Computational Biology position in Cambridge, MA. KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.

Position Summary

We are seeking an exceptional and highly motivated Computational Biologist to work on several projects focused on high-throughput CRISPR in vitro and in vivo screens, drug target identification and validation. The key objective will be transforming data into meaningful biological insights. This position will offer an exciting opportunity to develop new methods for the integrative analysis of genomic and functional data. The successful candidate will be a key team member driving computational analyses aimed at the development of novel therapeutics.


Key Qualifications

  • Ph.D. in Computational Biology, Bioinformatics, Computer Science or related field.
  • Candidate should have a track record of scientific achievements with a demonstrated history of algorithms development and getting insights from complex biological data.
  • Strong coding skills required, fluency in R and one of the scripting languages preferred.
  • Experience with cloud computing is highly desirable.
  • Experience with genomic data analysis is a strong plus.
  • A strong knowledge in biology is highly preferred
  • Commitment to quality, attention to detail, and team player mentality is a must.


  • Mining large-scale functional genomics screening data generated by KSQ biologists
  • Collaborating closely with Target Discovery, Target Validation and Immuno-Oncology teams on experiments design and data analysis.
  • Integrating internal and external datasets.
  • Identification of genomic features associated with cellular phenotypes of interest.
  • Presenting and communicating findings to the team.


A competitive overall compensation package including: competitive base salary, bonus potential and stock options.


To learn more about this exciting career opportunity, please forward your resume and background information in confidence to Dr. Gregory Kryukov at KSQJobs@ksqtx.comPlease refer to the Job Reference Number and Job Title in the email subject.