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Scientist, Computational Biology

Job Reference: #004

KSQ Therapeutics, Inc. has an immediate opening for a Scientist, Computational Biology position in Cambridge, MA. KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.

Position Summary

We are seeking highly motivated and enthusiastic Computational Biologist to work on analysis of data from functional CRISPR genomics screens aimed to identify key pathways involved in human disease. Successful candidate will work on computational challenges of developing new high-throughput platform, designing and implementing analytical workflows and databases. This is a great opportunity to play an essential role in highly collaborative and interdisciplinary team and ultimately to contribute to the development of novel therapeutics.

Key Qualifications

  • B.S./M.S. in Computer Science, Bioinformatics, Physics or other quantitative field
  • Strong coding skills with 3+ years of experience
  • Fluency in R and one of the scripting languages (Python/Perl) is required. Working knowledge of SQL is advantageous.
  • Previous experience in design and development of data processing pipelines and LIMS systems is very highly desired.
  • Prior experience in development of interactive web applications is a strong plus.
  • Ability and willingness to learn is a must


  • The successful candidate will focus on the development of data analysis and management pipeline for high-throughput functional genomics screens. This will include work on all stages of the process – from automation of raw data processing and QC to the design of databases and developing methods for results visualization, exploration and interpretation.


A competitive overall compensation package including: competitive base salary, bonus potential and stock options.


To learn more about this exciting career opportunity, please forward your resume and background information in confidence to Dr. Gregory Kryukov at KSQJobs@ksqtx.comPlease refer to the Job Reference Number and Job Title in the email subject.