Back to job listings

Associate Principal/ Principal Scientist – Oncology Cell-based Assay Development

Job Reference: #020

KSQ Therapeutics, Inc. has an immediate opening for a Associate Principal Scientist / Principal Scientist, Oncology Cell-based Assay Development position in Cambridge, MA. KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.

Position Summary

KSQ Therapeutics, Inc. is seeking an exceptional and highly motivated scientist with expertise in cell-based assay development. The successful candidate will develop and miniaturize cell-based assays for a variety of oncology drug discovery projects.  A key responsibility of this position is to successfully manage day to day CRO interactions including experimental direction, data management and analysis.  This position requires broad cell biology experience across various drug target classes.  The successful candidate will collaborate in a cross-functional team, with daily interaction across several groups, including biochemistry, chemistry, and target discovery.

Key Qualifications

  • Ph.D. with 3+ years / BS/MS with 8+ years of experience in small molecule drug discovery in an industry setting.
  • Core competencies should include designing, developing and miniaturizing SAR-driving cell-based assays for oncology programs; ideally across several drug target classes.
  • Experience coordinating and managing international CRO efforts highly desired.
  • Proven experience developing cell-based assays for use in drug discovery is essential; immune assay experience a plus.
  • Ability to think critically and creatively as part of a fast-paced drug discovery team.
  • Adaptability, commitment to scientific excellence, and a team player mentality is a must.



A competitive overall compensation package including: competitive base salary, bonus potential and stock options.


To learn more about this exciting career opportunity, please forward your resume and background information in confidence to Dr. Michael Lam at KSQJobs@ksqtx.comPlease refer to the Job Reference Number and Job Title in the email subject.