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Associate Director / Director: Medicinal Chemistry

Job Reference: #010

KSQ Therapeutics, Inc. has an immediate opening for a Associate Director / Director, Medicinal Chemistry position in Cambridge, MA. KSQ Therapeutics has built an industry-leading genome-scale precision functional genomics platform, called CRISPRomics, to pinpoint therapeutic nodes that directly correlate genomic function to disease with unprecedented certainty and speed. The company is deploying CRISPRomics for novel drug development across broad therapeutic areas and is advancing a proprietary pipeline of tumor- and immune-focused drug candidates for oncology. KSQ was founded by thought leaders in the field of functional genomics and pioneers of CRISPR screening technologies. The company is located in Kendall Square in Cambridge, Massachusetts.

Position Summary

KSQ Therapeutics is seeking an exceptional, innovative and highly motivated Associate Director / Director: Medicinal Chemistry to apply fundamentals of synthesis, SAR and structure-based design toward the optimization of chemical matter to advance our portfolio of drug development programs. This person will influence the company’s emerging NCE drug design organization and contribute strategically and scientifically to build a strong portfolio of novel drug candidates. As part of the team of scientists at KSQ Therapeutics, this individual will have responsibility for biological data interpretation, design of molecules, and development of structure-activity relationship as well as execution of the synthetic plan in collaboration with CRO partners. As part of a lead progression team, this individual will set the small molecule drug discovery strategy on multiple programs from hit triaging, hit-to-lead and lead optimization to deliver drug candidates that benefit patients’ lives. The successful individual will join a dynamic, enthusiastic, interdisciplinary, and collaborative team of scientists.

Key Qualifications

  • PhD in chemistry with 7+ years of industry experience with a focus on small molecule drug discovery or BS/MS with 15+ years of comparable work-relevant experience in the field of small molecule drug design
  • Extensive experience interfacing with, and providing scientific guidance to, CRO partners and proven ability to work efficiently in a hybrid model
  • Demonstrated expertise and a track record of success in advancing discovery programs from target validation through lead optimization and into clinical development
  • Broad expertise of successfully prosecuting a wide range of biological target classes and varied chemotypes
  • A track record of communicating scientific concepts and strategies effectively, including a publication record in top-tier, peer reviewed journals
  • Excellent verbal and written communication and interpersonal skills to work within a project team setting, across functions, and within academic and industry collaborations
  • Ability to independently solve problems, to think critically and creatively as part of a fast-paced research team.
  • Commitment to quality, attention to detail, and team player mentality is a must.

Responsibilities

  • Responsible and accountable for CRO partner interactions and alignment of resources consistent with the drug design team’s priorities and objectives to build a strong portfolio of drug candidates
  • Implement and seamlessly oversee synthesis, characterization and compound submission for biological profiling at CRO partner facility
  • Review, interpret and QC data from CRO partners
  • Contribute scientifically and strategically at both the drug design team and drug portfolio levels
  • Must be able to travel periodically, including internationally, to develop and foster collaborations with CRO partners
  • Develop and deliver scientific reports and presentations internally or externally as needed
  • Function in a scientific leadership role as part of an interdisciplinary team contributing to the design and execution of experiments in support of our research activities and project goals.
  • Participate in various aspects of this new fast-pace company from building out the capabilities, contributing intellectually and to generating data in a fast and efficient manner.

Compensation

A competitive overall compensation package including: competitive base salary, bonus potential and stock options.

Contact

To learn more about this exciting career opportunity, please forward your resume and background information in confidence to Dr. Rene M. Lemieux, at KSQJobs@ksqtx.comPlease refer to the Job Reference Number and Job Title in the email subject.